微生物药敏快速检测方法研究进展

敏慧 黄()

摘要

抗生素耐药性（Antimicrobial Resistance, AMR）已成为威胁全球公共卫生的重要因素之一。目前，临床常采用的抗菌药物敏感试验（Antimicrobial Susceptibility Testing, AST）是指导其合理使用抗生素、遏制耐药性蔓延的关键技术。然而，通过传统AST方法获得药敏结果耗时长，难以满足临床快速、精准用药指导的需求。因此，发展快速、准确、高效的AST技术已成为临床微生物学和精准医学的迫切需求。基于此种现状，本文系统性的回顾了近年来快速药敏检测（Rapid drug susceptibility testing technology，RAST）领域的新方法，从各类方法的原理、优势、局限性及相关的临床应用等方面进行深入分析，并探讨了快速药敏检测技术当前面临的挑战与未来发展方向，旨在为临床医务工作者、研究人员等提供相应的技术参考，促进快速药敏检测技术的临床转化与应用，提升感染性疾病的诊疗技术，最终能改善日益严峻的抗生素耐药危机。

关键词

抗生素耐药性；快速药敏检测；微流控；生物传感器；单细胞分析；分子诊断

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v3i10.33012