女童中枢性性早熟的诊断进展

畅达 李(1 承德医学院附属医院，中国;)
燕 王(2 承德医学院附属医院儿科，中国;)

摘要

近些年随着社会经济的发展，儿童性早熟的发病率逐年递增。儿童性早熟（Precocious puberty, PP)是指儿童青春期提前出现，在正常发育年龄之前过早地出现第二性征发育的疾病。根据下丘脑－垂体-性腺轴（HPGA）功能是否提前启动分为中枢性性早熟（CPP）、外周性性早熟(PPP)和不完全性性早熟（IPP）。CPP不仅导致儿童骨骼过早愈合，影响其成年身高，还会引起抑郁、焦虑、低自尊、低自信等一系列社会心理问题。不同类型的性早熟的诊疗差异显著，能尽早通过临床表现、血清学指标及影像学多维度评估出CPP，对于CPP患儿预后有重要的临床与心理意义。

关键词

中枢性性早熟；血清学指标；影像学；评估

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v3i10.33024