高原肠道菌群调控睡眠障碍的神经免疫机制与干预策略

永亮 朱(中国人民解放军联勤保障部队第九四〇医院，中国)
晓燕 张(中国人民解放军联勤保障部队第九四〇医院，中国)

摘要

高原低氧环境常导致睡眠障碍，严重影响人体健康与工作能力。目前，该病症的病理机制尚未完全阐明，且缺乏有效的防治手段。近年来，肠道菌群作为环境与宿主生理之间的关键桥梁，在低氧所致睡眠障碍中的作用日益受到关注。本文基于“肠脑轴”理论，系统阐述了高原低氧引起肠道菌群结构紊乱、破坏肠道屏障功能，进而通过免疫炎症激活、神经递质代谢异常及中枢调控失调等多途径引发睡眠障碍的级联机制。重点分析了关键菌群代谢产物在其中的中介作用，并探讨了益生菌通过多靶点修复肠道屏障、调节免疫稳态及恢复神经递质平衡以改善睡眠的潜力，为高原睡眠障碍的防治提供新的理论依据与转化路径。

关键词

高原；睡眠障碍；肠道菌群

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i11.34536