布比卡因脂质体注射液在骨科手术中的应用

迎凡 常(承德医学院研究生院，中国;)
红绪 靳(衡水市人民医院麻醉科，中国;)

摘要

布比卡因脂质体利用缓释技术可实现长达96小时的术后镇痛。在膝关节置换、肩关节手术、髋部骨折及脊柱融合等骨科手术中，其镇痛时效优于传统局麻药，能显著减少术后阿片类药物用量，并有助于促进患者早期康复、缩短住院时间。安全性方面，由于其峰值血浆浓度较低，发生全身毒性反应的风险低于传统布比卡因，且不良事件谱与之相似。药物经济学研究提示，尽管单次采购成本较高，但其改善镇痛质量、减少并发症的效果可能带来综合成本效益。不过，该药的广泛应用仍面临挑战，主要是价格昂贵、不同手术的给药方案尚未标准化，以及疗效存在个体差异。未来需要更多大样本研究来优化应用策略，明确其药物经济学优势，以更好地在加速康复外科中发挥作用。

关键词

布比卡因脂质体注射液；神经阻滞；镇痛：骨科手术：区域阻滞

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v9i3.37316